Changes in cholinergic and glutamatergic markers in the striatum from a sub-set of subjects with schizophrenia

B Dean; N Thomas; CY Lai; WJ Chen; E Scarr

Journal article

Changes in cholinergic and glutamatergic markers in the striatum from a sub-set of subjects with schizophrenia

B Dean, N Thomas, CY Lai, WJ Chen, E Scarr

Schizophrenia Research | Published : 2015

DOI: 10.1016/j.schres.2015.10.028

Abstract

Background/objectives: Having separated a sub-group of people with schizophrenia based on a marked loss of cortical [3H]pirenzepine binding (MRDS); we wished to determine if MRDS had lower levels of [3H]pirenzepine and other muscarinic receptor antagonist binding to the striatum and if this was due to loss of pre- or post-synaptic neurons or glia measured using surrogate markers (25kilodalton synaptosomal-associated protein (SNAP 25), postsynaptic density protein 95 (PSD 95), glial fibrillary acidic protein (GFAP) 41/43) of cell number. Methods: [3H]pirenzepine, [3H]AF-DX 384 and [3H]4-DAMP binding to the striatum from 37 subjects with schizophrenia (19 MRDS) and 20 controls as well as SNAP ..

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University of Melbourne Researchers

Brian Dean Author Florey Department of Neuroscience and Mental Health

Natalie Thomas Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This research was funded by the NHMRC, the Victorian Government's Operational Infrastructure Support and the Rebecca Cooper Medical Research Foundation, none of which had any influence over the generation of data or the writing of the submitted manuscript.